Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19

Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry CRS in presence and absence of Arg guanidino group occupying position 2 Ang II. These findings suggest that Tyr is over His bearing negative stabilized by group. Recent crystallography studies provided details binding nonpeptide angiotensin blockers (ARBs) type 1 (AT1) receptor, these insights applied A model activation explains surmountable insurmountable effects analogues sarmesin sarilesin, respectively, was developed enabled discovery new generation ARBs called bisartans. Finally, we determined ability bisartan BV6(TFA) act as potential ARB, demonstrating similar candesartan, reducing vasoconstriction rabbit iliac arteries response cumulative doses clinical have shown protective hypertensive patients infected with SARS-CoV-2. Therefore, usage ARBS block AT1 preventing toxic implicated storm cytokines SARS-CoV-2 target treatment opens avenues disease therapy.